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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '89d195ccc9c04ff515e5e8180866c6aded6aa47d390d8e85eae03749c4b5e268' 
  AND token = 'Vg2XzP49MDn2WyB2gE1h/X7tH3HMltlSCv8ZIes2jbQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}