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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22277769e8d6e73defc25c89bfbb115e3f2c192be1925d2c50da06d4d1904025' 
  AND token = 'PYmzK9hgLn74J8BC95dSQuuY3270RqdKnYL8bIJHFxM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}