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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f4486bad94f10f71d97a53ed0ea3f670c837e98b9444d606984d0e7403e9fc81' 
  AND token = '+AGudnhyAcsTTS4RylS3AZ+4Os3tqT9FaWL5VlOXCFo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}