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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f0ca23c43ef4e7240600f7fb2001ef75e403e1045d014245688b826087ea1889' 
  AND token = 'EZ6Hnh7h6Y1hLalvAW/iH5CGjEH3N9nTPJc69EZL/4I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}