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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '043100d008240cddd81b74e110e7126e3bda508df949c2e742ff27b373b4bc40' 
  AND token = 'R0uaxvPFHCRw4zntiMGcYAPpk7AOkLoM2uVO5MuoZA0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}