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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4427211f2232d0d61760e6eb0f8394166de33ea61fcab83fc0b10c6e6a5d7e31' 
  AND token = 'LcR6EGCMwe2qwDOzv9J9z1MzEbm3IZISWPUrxpuQnco=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}