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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8d65e1c0fe88f9541396eea19b18113566958c160eca808cb7be1241ba6e4b64' 
  AND token = 'r/4rjqUlbtDlUkpXKKV+EcRrkU4R/1Os8tM3regCo00=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}