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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2c5726f6db44c60d21db73c0e9da1c748babd38b3f30e9aec7c48993d6244b4a' 
  AND token = 'KktVBn1unqDRwfQUWQK+DFlZehe5CPwes09qripTQBQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}