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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e7346aeb8db84d185491bb4774319d27963330d4ec8bc3319e5721d0aca279d' 
  AND token = 'VJ2XEC+/AfbMKKUMVzhKax1WtW8che71qxLQqHpxf0o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}