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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65a44e37c07253bfe18bdbc0cad4282039a991a7a8990d025b43f0e9e8b02159' 
  AND token = 'bN7OPnrUFLNBbcGuYwe1pVXFqCI1Y/dumXKwbY6oDyU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}