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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e45428f293e11940f1f246cee63e2319e7b55849a987eb34f5373c1272b0d0a3' 
  AND token = 'fuPJSswjfSJ2kerMkJJrA7lPFONzaDesXojPCn0S1xw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}