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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4a314c4063a8c022ceacd4bef9d005a2691b2d3794dfe9cb80a6e8d7e7f4517f' 
  AND token = 'HO6M9o9EiSMBKiGBN5FWcpEotr6ghUqtdO0UMbAGj9Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}