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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8cdb5a8ea8438b8d9c467926d650079cf15f72c5c1697dfec78690484b462eb1' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}