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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'eadf571b38cd0783dd6bc83ccb02838f7f5589ea20acace2f4f453c367890169' 
  AND token = '63XM73mJCuE5adrX35H+j291aKt4YX+JhRSUPhRwNVA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}