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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52b2aa70d7bfeec78f70333300b017d9b582da29c6894fa5009d9fc8e0c9fb6a' 
  AND token = 'i85DHWaXPgnQ/hVbAhTfnOp4YmViwhTKYe0BKYsdPv4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}