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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49efb2b16bd80fd587287cd57c539f44557c40ad08834f6655c8d6afef2f5bc7' 
  AND token = '2D1uIRG8ehc+TFCmZCoDhpvhQTJpreAzubY41DIElC8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}