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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81810e3eccdab2d562f6c78fa63d0bc8687364ace3b4d3b1f9d65f6c5ba01748' 
  AND token = 'gC8GVG1LnDDqnrHj3OqZYjLJ7d2TT3WQeloycxeiXqU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}