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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6db12bdf0b2a756ba74d1d1a0907faf94e5088da66784ac18a4b594fad4b1ede' 
  AND token = 'QcRvd6I+sCd5/nV6e7+BpWDIVAASUtLYZ+4rH0slapQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}