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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'adfdf1001b0a3d8607f9e9b399597fd67f8c2ccb1cdd81927afc9663306a1a8c' 
  AND token = 'nIHoM3IF+T1Nthf++4BON1ZTddrLIoA0uXxJHvz1cPw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}