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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f466906f2dd2f7d8f17092dcc02541736d1b2b41d3f9e179932df749e4fd6c37' 
  AND token = '2yyAbnXvqp1D2HqZfxVE4C2l/i8phCTz8V+SIuZHkQ0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}