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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8e12d6e782262bee14516dc947e1fd996ee1ba47e916c9f5c0953303dd5fecad' 
  AND token = 'EQC9npi45AwB802AYbwSRdSeUjJluP3TgDzV21gICPs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}