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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5225f5f2e03223dbcb31ba282e50610f3b66033f722612d859a338ef81fe6e21' 
  AND token = 'aiHH2q3RcA7Tv1RmSPrCUYwUoEf0JugNr+hosPyp+xA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}