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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b64b2796932ced022660437db3da4e3c76089f15f4daa770978d36a40ca59e9e' 
  AND token = 'DiD3hQihBF8KeT1NAC6kP1D07E6/8JyIjeA7S+/p7Ls=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}