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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2a4e7fc457cf3022aa852a370d52611552f0d68bc3eee37c8f99b817b72fee8e' 
  AND token = 'tpGoyITDKvUeh4cJ+ZTSN17WVmRRtBTwFp7Ss4PkicI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}