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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22f50efdc9136199eb5089a0ee7004aa1b8382797070d84806e7d11a673dba0d' 
  AND token = '+kJ5qUwzuoMoXlmvBHHJWJsz0WYWi0umA+s6ZOsOMr8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}