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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '654039c8f946451e7c534c536c993b6366b2d633772330eceffd0b001dfce20c' 
  AND token = 'RYeT07LOM7IdYdj+WGNJYgRWRUW4bXzQGmey4Ywd0ds=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}