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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2e31290b783deb6c32cd31c3937eade99044afe49fe6dbe87120843e422cc111' 
  AND token = 'HQQYSBWGWlB1yrSHImjI/zL7aWbeGSXru7/dVb13nQ0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}