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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3d250c615fca3add4048b2911e664701ee620b650e67d6c1a940440513256fec' 
  AND token = 'O66Cn/QGCI4H9oNoVGVOe4ogaed9ANsiw+rQ29mNWPY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}