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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'bc49a15b7f1c45772fbd02a645318a1f87f1ea4ff682ce30add6f4ca9fe0b401' 
  AND token = '0wPOYx4wRRrhpTSuNgldJkpNkSBKbyfSX61uSn77Gwk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}