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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '57af45c4c1dbbeaf276f14ff4bbccb6a1e9327a9ea4494e2e7fc3e4e5384b1b4' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}