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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '100339a48cb5c6fab2460eb0a820a57a04ad96e6aa06f6d92f805f8827d5555a' 
  AND token = 'Hxvy7WrcON0d0xcPu63Rs/ypA9GUGOar6bwmWGKzFfA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}