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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3e141776be4034f00d8997d3ac551257ad38cf76e5212d075cb1a2a6c3418201' 
  AND token = 'SQwNfg6ow9cw/VQfMrleSc8rdLGX2ku1z/+9lhoo2EU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}