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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78b0deb3fdd8df3b1819e3b0d0ebf72ba6f779b95517243f46b106fa16136343' 
  AND token = '4lwS+ZjWkK/7O4hnOQV0rFn2jRYTdpFV2ypaogS/9as=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}