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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a10ded2cc0692ab7a7d2c414d3405109881a7aeca0ce89b407bacf70e92d0bf3' 
  AND token = 'AFR3eOu1B2g2DK2BWFd6iq/LjdP6FWDLhBxS7MZlGLs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}