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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e0ac1cf4081307a46602d2635002882e925da86eba2127537a289aab12250619' 
  AND token = 'DUf6odL7OEaOdDGT2FzPCgk/3yFpTicrCOwPD5/eU6k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}