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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7345018a2c5a07b9b31915b703e16d7ef04b5a30d7158baf35e3a1071f9f7176' 
  AND token = 'CpAqpIlt33UgIow5SxmVw8qJKSHMaqKrD6HxUiGINxQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}