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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '91221d675759f8909a4d3800f3f4d6164474103886b885ae641d913a31a916fa' 
  AND token = '59SWN18NnviTp8JsKurzFmsGZnf2527alPRK0l3HWOE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}