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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7e25c1b635404ca32f87086b0dd4074f5e1f324fb70d961b95c66b5a9a71bb2f' 
  AND token = 'ZQ/3FFgG85JufB0sXOxFfk/2kY4fhH81RZaRFmKIYD0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}