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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6cb2ad2472dd80a6b8a0784e9aa7126f13ce3c332f98e20195c17873cac00a49' 
  AND token = 'Wr0Mh/z+AoGoF7TpxEUA+rFcs8Yar1O/Ovo2uxJdp5A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}