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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '180f17422bbd58f15bcee68179bde736ed9b0ceb6437ce3dfdf791eac7a72853' 
  AND token = 'cxk0IczKm3e/0rYezbTMlYIXGK0i29R/saj3atWbIto=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}