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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '68a462afe35a997f04040b8d4ab4ddba36dee2500e76ac2229b36d093c240446' 
  AND token = 'JZkP+nC7C22SMQxuBIQt+l4XPFx/08HwzxJO4DZ9uP8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}