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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49d49c3579c291627dcece04e1e4a562b7f2022175afdc41dfc91519d2bbf7b1' 
  AND token = '6jrG3tXwHlU+8gi6wgj299yyb4vYq4KP25mGHDbkEo8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}