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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed1a9a6667dc253dd09961832ceac3f90dac58011786b06f9aa528b5a6a01043' 
  AND token = 'XkSJpK39MYK0VU1d+JUx4CYcO3YCb2PfvgxwBlEA6gs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}