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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de54c65dbd4faa5abe2b9a596e7d0c74646021397afb908e98f1c5d035357758' 
  AND token = 'rENQdT1Gecb7JRduhejhHkBCzRrwRlh3tsCcNctaRuc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}