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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed8c8267462a4d4da0602d7cd7f199348958113621e673368ded4020cafebec3' 
  AND token = 'otPoHzFcSSPUNDQArbjSyoMlatZg+4y+deY0wLuEGu4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}