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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '622d9b5b045550d6f754627d93a52294565900bd4d72c003bdbc469855b6c305' 
  AND token = 'i2seDNNW8CAGmFct8/ObsxPWj602LAE0SAkr/dgVPiI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}