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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '28bdc7ebc98b13bbb4fc97f899f83445dcf481b806965d20f167de760e0e2008' 
  AND token = 'F6jJTIl0Y/S8ePf+Q6oJwjQN0LSnmmZa+FvMjQcrh+A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}