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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3e3d20745d169f3485fd4df1f96c8f4f95b2ed3e3b8294ddd32e1e5966af53d9' 
  AND token = 'UmzaK3k3/EFo3ziaAW/3ZhFBM29S/OC1YGrCcOtYiW4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}