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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5557ce859c3e33cf7f0f3c5be0af463028e93103e3dc3fb16ec2913220ff7527' 
  AND token = 'KTuq55/Ntex2q2ZQ0XbxSCaaJ97KRhFIni+8Lmv9BT8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}