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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2d900184246de25981f492e02bf48f1da0915ad8568bd80ca41c70b5fc2b4a44' 
  AND token = 'GJLgCFQ2EbBFCr78zjjNhsM97Hv1Q+8IC2MB53E0Pak=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}